Improve Diagnostic Confidence in Liver Health - Ultrasound Derived Fat Fraction Values
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For the proper use of the software or hardware, please always use the Operator Manual or Instructions for Use (hereinafter collectively “Operator Manual”) issued by Siemens Healthineers. This material is to be used as training material only and shall by no means substitute the Operator Manual. Any material used in this training will not be updated on a regular basis and does not necessarily reflect the latest version of the software and hardware available at the time of the training.
Improve Diagnostic Confidence in Liver Health siemens-healthineers.com/ultrasound 11726 0322 · ©Siemens Medical Solutions USA, Inc., 2022 Liver assessment using ultrasound gray scale findings alone can be difficult when determining relative tissue stiffness or fat content. Remove subjectivity to improve diagnostic confidence by using Virtual Touch elastography technologies to determine liver tissue stiffness and the Ultrasound Derived Fat Fraction (UDFF) to quantify fat content in the liver. The degree of tissue stiffness has been shown to correlate with the progression of liver fibrosis. Livers that are high in fat content also show an increased level of tissue stiffness 2 and associated fibrosis. 7 8 4a 1 3 4b IQR/Median Ratio Recommendations 6 5 pSWE/2DSWE: < 15% (m/s), < 30% (kPa) Auto pSWE: < 30% (m/s), < 60% (kPa) Absent or mild fibrosis Significant fibrosis Severe fibrosis Cirrhosis Metavir Score F0–F1 F2 F3 F4 Siemens Healthineers 1.2 m/s 1.3 m/s 1.5 m/s 1.7 m/s values* 4 kPa 5 kPa 7 kPa 9 kPa 1.3 m/s 1.5 m/s 1.7 m/s 2.1 m/s Society of Radiologists in Ultrasound (SRU)* < 5 kPa Likely Normal < 7 kPa Unlikely cACLD 7–9 kPa Potential cACLD > 13 kPa Highly suggestive > 9 kPa Suggestive of cACLD of cACLD IQR/Median < 15% m/s, < 30% kPa. cACLD = compensated Advanced Chronic Liver Disease. This guide is based on meta-analysis and clinical studies using Siemens Healthineers Ultrasound. This guide is not intended to be used as a conversion table for liver stiffness readings to fibrosis stage or replace the performing physician’s judgment for the final diagnosis. DAX Ultrasound Derived Fat Fraction (UDFF) Liver Site 1 Abdomen Vs Median=1.40 m/s TIB:0.85 E Median=5.9 kPa TIC:2.29 UDFF=14 % TIS:0.85 Depth=5.2 cm MI:1.38 UDFF 29fps 0%–5% > 5% 95% 5% 2D H Mid 8dB/DR60 c=1540 No Hepatic Steatosis Hepatic Steatosis PSWE (S0) (≥ S1) UDFF delivers a similar clinical utility to Magnetic Resonance Imaging Proton Density Fat Fraction (MRI-PDFF) for determining hepatic steatosis. Both methods classify hepatic steatosis as an index value of greater than 5%.* For more information, please visit siemens-healthineers.com/ultrasound or contact your local Siemens Healthineers sales representative. SIEMENS * Data on file. Healthineers
- liver
- best practices
- fibrosis
- steatosis
- hepatic
- UDFF
- ultrasound derived fat fraction